Transgender and gender diverse (TGD) people are at particularly high risk of experiencing traumatic invalidation, which is defined as extreme or repetitive invalidation of a person’s significant experiences, characteristics, and reactions (Linehan, 2015). Now more than ever, TGD people are experiencing extreme invalidation at interpersonal (e.g., verbal harassment), institutional (e.g., being denied health care), and systemic levels (e.g., executive orders denying the existence of TGD identities). These types of invalidating experiences increase risk for mental health problems, such as PTSD, suicidality, emotion dysregulation, and depression, all of which disproportionately impact TGD people. In this webinar, we will provide examples of traumatic invalidation related to TGD identities and discuss how to tailor the DBT Prolonged Exposure (DBT PE) protocol for PTSD to the needs of TGD clients. Case examples will be used to illustrate common issues that arise when delivering DBT PE to TGD clients, including how to help clients cope with ongoing invalidation in their lives. Finally, we will discuss strategies therapists can use to maximize their own ability to sustain this life-saving work, particularly when working in organizations that adopt anti-transgender policies.